摘要
为探讨肝素在冠心病治疗中的作用，将２０例冠心病患者分两组进行比较分析。Ａ组：肝素加运动，共１０例患者，按标准方法进行２０次踏车运动试验，每次踏车运动前２０分钟静脉注射肝素钠５０００Ｕ；Ｂ组：单独肝素组，共１０例患者，进行皮下注射１０次，每次肝素钠１００００Ｕ，试验期间不做运动试验。全部患者在第１次应用肝素前２４小时和最后１次应用肝素后２４小时均行症状限制性踏车运动试验。在Ａ组，运动总时间从７．１３±０．８９分钟（ｘ±ｓｘ，下同）增加到１１．６７±１．０４分钟（Ｐ＜０．００１），最大血压心率乘积从２４０４．００±３１２．００ｋＰａ／ｍｉｎ增加到３１８２．００±４９５．００ｋＰａ／ｍｉｎ（Ｐ＜０．００１），而Ｂ组上述参数无明显改变。结论：肝素配合运动能够加速侧枝循环的建立，而单独应用肝素则无此作用。运动诱发心肌缺血可始动肝素再生血管的作用。本试验为冠心病的治疗提供了又一新的、有效的。
The aim of this study was to investigate the effect of heparin in treatment of coronary heart disease.20 patients with stable angina were randomly divided into two groups.Group A(n=10):bicycle exercise was performed twice a day for 10 days according to the standard protocol;a single dose of heparin (5000U) was given intravenously 20 minutes before each exercise.Group B(n=10):heparin (10000U)was given subcutaneously once a day for 10 days without bicycle exercise;symptomatic limitative bicycle exercise was performed in all patients 24 hours before and after treatment.In group A,total exercise time was increased from 7 13±0 89 minutes ( x ± s x ) to 11 67±1 04minutes( P <0 001),and the maximum product of blood pressure and heart rate from 2404±312kPa/minute to 3183±495kPa/minute ( P <0 001),In contrast,the above mentioned parameters of bicycle exercise in group B,remained unchanged.It is suggested that,without combined exercise,heparin alone does not accelerate the development of coronary collateral circulation.Heparin potentiates the ischemiaderived angiogenic factor.This study provides a new,effective and practical therapy for patients with coronary heart disease.
出处
《中国危重病急救医学》
CAS
CSCD
1996年第5期281-283,共3页
Chinese Critical Care Medicine
