摘要Alzheimer 病(AD)是造成中老年人智能障碍的重要疾患,它是与记忆过早丧失有关的神经变性疾病。发病年龄以40～65岁居多,常以50岁或55岁以前发病者为早发型,60岁以后为晚发型。高龄人群中 AD 患病率约为5%,AD 先证者10～20%有家族史,据估计我国百万之众的 AD 病人中约10%有明确的遗传背景,
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