期刊文献+

糖尿病视网膜病变的药物治疗进展

Recent progress on the drugs treating diabetic retinopathy
原文传递
导出
摘要 糖尿病视网膜病变是最常见的糖尿病微血管病变。目前有很多致力于延缓糖尿病视网膜病变的药物研究,包括对肾素-血管紧张素系统阻滞剂、蛋白激酶C抑制剂、血管内皮生长因子抑制剂、生长抑素类似物、抗炎药物、晚期糖基化终末产物抑制剂及醛糖还原酶抑制剂等的研究。本文就近几年在这些方面的研究工作作一综述。 Diabetic retinopathy, the most common microvascular complication of diabetes, is the leading cause of blindness. Many methods or drugs have been used to prevent the development of it, including iulfibition of renin-angiotensin system, protein kinase C iuhibitors, inhibitors of vascular endothelial growth factor, analogs of somatostatin, anti-inflammatory treatment, advanced glycation end products inhibitors, aldose reductase inhibitors, etc. This review focuses on the recent investigations in medication of diabetic retinopathy.
出处 《国际内分泌代谢杂志》 2006年第B04期3-6,共4页 International Journal of Endocrinology and Metabolism
基金 上海市科委科研计划项目(034119818)
关键词 糖尿病视网膜病变 蛋白激酶C 血管内皮生长因子 生长抑素类似物 晚期糖基化终末产物 醛糖还原酶 Diabetic retinopathy Protein kinase C Vascular endothelial growth factor Analogs of somatostatin Advanced glycation end products Aldose reductase
  • 相关文献

参考文献21

  • 1UK Prospective Diabetes Study (LJKPDS) Group. Risks of progressian of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69. Arch Ophthalmol, 2004,122:1631-1640.
  • 2Moravski CJ,Skinner SL,Stubbs A J, et al. The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes: transgenic and interventional studies. Am J Pathol, 2003,162 : 151 - 160.
  • 3Zhang JZ, Gao L, Widness M, et al. Captopril inhibits glucose accumulation in retinal cells in diabetes. Invest Ophthahnol Vis Sci, 2003,44:4001-4005.
  • 4Zhang XL, Lassila M, Cooper ME, et al. Retinal expression of vascular endothelial growth factor is mediated by angiotensin type 1 and type 2 receptors. Hypertension, 2004,43: 276-281.
  • 5Mori F, I likichi T, Nagaoka T, et al. Inhihitory effect of lo.sartan, an AT1 angiotensin Ⅱ receptor antagonist, on increased leucocyte entrapment in retinal microcirculation of diabetic rats. Br J Ophthalmol, 2002, 86:1172-1174.
  • 6Sjolie AK, Porta M, Parring HH, et al. The DIRECT Programme Study Group.The Diabetic Retinopathy Candesartan Trials (DIRECT) Prograting: baseline characteristics. J Renin Angiotensin Aldosterone Syst,2005,6:25-32.
  • 7Nonaka A, Kiryu J, Tsujikawa A, et al. PKC-β inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats.Invest Ophthalmol Vis Sci, 2000,41 : 2702-2706.
  • 8The PKC-DRS Study Group. The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy : initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes,2005,54:2188-2197.
  • 9Yokota T, Ma RC, Park JY, et al. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes, 2003,52:838-845.
  • 10Poulaki V, Qin W, Joussen AM, et al. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1 and VEGF.J Clin Invest,2002,109:805-815.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部