摘要
将黄芪、黄连、黄芩三昧中药联合组方，制成三黄合剂和心脉胶囊。用单光子发射型计算机断层（ＳＰＥＣＴ）核素心血池扫描观察三黄合剂或心脉胶囊对在心室功能的作用。静脉注射三黄合剂能明显提高犬左心室射血分数（ＬＶＥＦ）３３．７％（ｐ＜０．０５），缩短相角程（ＬＰＨ）１５．７％（ｐ＜０．０５）。但是临床上给陈旧性心肌梗塞患者口服心脉胶囊均无明显变化。对引起动物实验与临床效果不同的可能原因进行了讨论。
Astragalus membranaceus,Coptis chinensis and scutellaria baicalensis were mixed and extracted with boiling water. The decoction is named Sanhuang Mixture(SHM)and its cap-sulized preparation called Xinmai Capsule(XMC).The effects of SHM or XMC on left ventricLilar hnction were observed with single photon ernission computerized tomograpl1y(SPECT)of radionu-clide cardiac blood一pool imaging SHM intravenously given significantly increased the left ventric-ular ejection fraction(LVEF) by 33.7%(P<0.05)and shortened the left、ventricular phase width(LPH)bv 15.7%(P<0.05)in canine. As for patients with old mvocardial infarction,two week treatn1ent with XMC did not significantly change LVEF, peak filling rate(PFR)and LPH. The possible reasons of the quite different restilts between canine and patient were discussed.
出处
《中国实验方剂学杂志》
CAS
1996年第1期32-35,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
黄芪
黄连
黄芩
核素心血池
左心室功能
药理学
Astragalus Membranaceus,Coptis Chinensis,Scutellaria Baicalensis.Left Ventric-ular Function,Radionuclide Cardiac Blood-pool Imaging
