摘要
目的:评价和比较共生菌、致病性口腔念珠菌感染的种类及对3种抗真菌药氟康唑、5-氟胞嘧啶和伊曲康唑的药物敏感性。方法:收集临床菌株,经YBCTestKit鉴定其念珠菌种类;根据NCCLS的M27-A2标准方案,测定3组(共生菌、口腔念珠菌病、头颈部放化疗患者合并口腔念珠菌感染)菌株对3种抗真菌药物的最低抑菌浓度。结果:3组临床分离株对5-氟胞嘧啶全部敏感,3组对氟康唑和伊曲康唑均有一定的耐药比例,放化疗组的非白色念珠菌比例及耐药比例明显高于正常共生菌组和口腔念珠菌病组。结论:共生菌和致病性口腔念珠菌均对氟康唑和伊曲康唑存在一定的耐药比例和交叉耐药比例。
PURPOSE： To evaluate and compare the sensitivity and resistance of commensal and pathogenic oral Candida to antifungal agents. METHEODS： YBC Test Kit was used to identify species of commensal and pathogenic oral Candida; The in vitro susceptibilities of oral Candida to 5-flucytosine （5-FC）,itraconazole （ITR） and fluconazole （FLU） were determined by NCCLS M27-A2 method. RESULTS： All strains were sensitive to 5-flucytosine, drug resistant strains to fluconazole and itraconazole were found both in commensal and pathogenic oral Condida spp; The proportion of no-C.albicans and antifungal drug resistant strains isolated from head and neck cancer patients treated with radiotherapy or chemotherapy were higher than oral commensal Candida and oral Candidiasis. CONCLUSIONS： The no-C.albicans and drug resistant strains to fluconazole and itraconazole can be found both in commensal and pathogenic oral Candida spp now.
出处
《上海口腔医学》
CAS
CSCD
2006年第2期218-220,共3页
Shanghai Journal of Stomatology
