摘要
给予Wistar大鼠含硒分别为0、2和4μg/ml的饮水,一半动物并给BP诱导,四周后显示,其血硒和肺硒含量升高,肺中谷胱甘肽硫转移酶(GST)活性高于对照。BP对芳烃羟化酶(AHH)的诱导受到抑制。补硒使其肺S-9的UDS效应值降低,抑制了BP对细胞DNA的损伤,这可能是硒抑癌的重要原因之一。
Wistar rats received respectively O, 2 and 4 ppm Se as Na_2 SeO_3 in the drinking water for 4 weeks,Half of them were induced by BP(10mg/kg, i.p). The results showed that the Se level in the bloodand lung of the rats increased significantly. The administration of Se increased the glutathione-s-tra-nsferase activity of the rat lungs and inhibited the induction of BP to the aryl hydrocarbon hydroxy-lase activity of the lungs. The supplementation of Se as Na_2 SeO_3 could significantly reduce the UDSeffects induced by BP in the rat lung s-9 segment-lymphocyte-UDS system. This indicated that theanticarcinogenesis of Se in animal was mediated through the effects of metabolism on PAHs in thelungs.
出处
《北京医科大学学报》
CSCD
1990年第5期373-375,共3页
Journal of Peking University(Health Sciences)
关键词
亚硒酸钠
肺脏
苯并(A)芘
GST
Sodium Selenite
Lung Benzo(a)pyrene
Glutathione-s-transferase
