摘要
在旋毛虫感染小鼠模型上,体内和体外实验都证实悬挂旋毛虫幼虫单克隆抗体的免疫脂质体(^(14)C-POPC/Chol/PA),在幼虫体内的含量远高于对照脂质体。实验结果表明,免疫脂质体可以提高脂质体的靶向性,为脂质体作为药物载体应用于临床治疗旋毛虫病提供了理论依据。
On the model of mouse infected with Trichinella spiralis, it was found that the immunoliposome,which was prepared by linking monoclonal antibody to Trichinella spiralis larva with the liposome(POPC/Cholesterol/PA), increased liposome targeting to larvae of Trichinella spiralis. The amountof immunoliposome uptake by skeletal muscle parasitized with Trichinella spiralis larvae increased by235% as compared with that of control liposome (P<0.001). In vitro immuoliposome uptake byincubated Trichinella spiralis larvae was 8-fold more than control liposome uptake (P<0.01). Theseresuls suggest that immunoliposome, as a drug-carrier, increases liposome targeting, thus it couldincrease the drug therapeutic effect, and immunoliposome may be available for clinical anti-trichini-asis.
出处
《北京医科大学学报》
CSCD
1990年第3期165-167,共3页
Journal of Peking University(Health Sciences)
关键词
脂质体
旋毛虫病
单克隆抗体
Liposome
Monoclonal antibody
Trichiniasis
