摘要
用不同剂量前列腺素Ｅ１（ＰＧＥ１，１００μｇ·ｋｇ－１体重、５００μｇ·ｋｇ－１体重）注入急性梗阻性胆管炎（ＡＯＣ）大鼠腹腔，设立盐水对照组，观察动物不同时间的死亡率，并检测血液内毒素、肿瘤坏死因子（ＴＮＦ）浓度变化趋势。结果：大剂量ＰＧＥ１组死亡率明显低于盐水对照组；各组血液内毒素变化无显著差别，均随时间延续呈上升趋势；３组ＴＮＦ浓度呈上升后下降，治疗组趋势平缓，高峰推迟。证明大剂量ＰＧＥ１对ＴＮＦ有抑制作用，可降低ＡＯＣ大鼠死亡率。
Rats with acute obstructive cholangitis(AOC) were injected different doses of prostaglandin E 1(PGE 1)(100μg/kg and 500μg/kg)intraperitoneally.Saline group was served as the control.The mortality rates at 6,12,18,24,48 and 72h were observed and the plasma endotoxin concentration and tumor necrosis factor(TNF) concentration were examined.The results revealed:the mortality of large dose group was significantey lower than saline group;endotoxin concentration in all groups increased persistently and there was no significant difference among these three groups;TNF concentration in each group increased first and then decreased,the changes in treatment groups were gentle and their peak values were postponed.It was demonstrated that large dose of PGE 1 could inhibit the action of TNF and decrease the mortality of AOC rats.
出处
《中国危重病急救医学》
CAS
CSCD
1996年第3期145-146,共2页
Chinese Critical Care Medicine
