摘要
本文报道了用导数光谱法测定磷酸丙吡胺的尿药浓度,本方法能消除尿中杂质干扰,测定结果准确。6名受试者交叉口服磷酸丙吡胺缓释片和普通片,测得尿药浓度计算消除速度常数K,排泄速率(Δx/Δt)_(max) 所需时间,证明缓稀片药物排泄慢,药效维持时间长,且缓释片的相对生物利用度与普通片基本相同。
First derivative spectrometry was selected for determining levels of disopyramide in urine. Six subjects took part in investigations both on disopyramide sustained release tablets and onplain tablets in a cross over way. There is no significant difference in the relative bioavailabilitybetween disopyramide sustaincd release tablets and plain tablets.
出处
《北京医科大学学报》
CSCD
1990年第1期67-69,共3页
Journal of Peking University(Health Sciences)
关键词
尿药浓度
丙吡胺缓释片
生物利用度
Disopyramide sustained release tablets
First derivative spectrometry
Bioavailability
