晚期非小细胞肺癌4种化疗方案临床对照研究被引量：22

Comparisons Among Four Chemotherapeutic Regimens for Advanced Non-small Cell Lung Cancer

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摘要 [目的]比较长春瑞滨、吉西他滨、紫杉醇、多西紫杉醇分别联合顺铂方案对晚期非小细胞肺癌的疗效及毒副反应。[方法]125例晚期非小细胞肺癌患者随机分为NP组(长春瑞滨+顺铂)、GP组(吉西他滨+顺铂)、PP组(紫杉醇+顺铂)、DP组(多西紫杉醇+顺铂)。长春瑞滨25mg/m2,吉西他滨1000mg/m2,第1、8d使用,紫杉醇135mg/m2,多西紫杉醇75mg/m2分为第1、8d使用,顺铂60mg/m2,分3d使用。21d为1个周期。[结果]NP组有效率(CR+PR)为39.4%,GP组为32.1%,PP组为36.8%,DP组为38.5%,差异无显著性(P>0.05)。对曾经使用过NP、GP、PP化疗的患者,DP方案还有33.3%的有效率。4组均出现不同程度的白细胞、血小板下降,恶心呕吐及腹痛腹泻。但各组有其特殊毒副反应,NP组表现为周围静脉炎,GP组为皮疹,PP组及DP组为关节肌肉酸痛。[结论]4种化疗方案疗效是相近的,应根据毒副反应的不同合理地选择化疗方案。

作者崔同建刘振华陈峥张桂枫

机构地区福建省立医院

出处《肿瘤学杂志》 CAS 2006年第2期136-138,共3页 Journal of Chinese Oncology

关键词癌非小细胞肺长春瑞滨吉西他滨紫杉醇顺铂药物疗法

分类号 R734.2 [医药卫生—肿瘤]

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参考文献8

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