摘要
为探讨慢性肺心病（ＣＰＨＤ）患者红细胞变形性变化机制，测定了３０例ＣＰＨＤ患者及２３例正常人红细胞变形性。红细胞膜流动性，并观察了扫描电子显微镜下红细胞形态。结果，ＣＰＨＤ及对照组红细胞滤速（ＥＦＲ）分别为３２．７１±１３．６１及２４．４３±１０．６１（Ｐ＜０．０１）；红细胞膜微粘度（η）分别为４．１７±０．１５及３．３１±０．１３（Ｐ＜０．０５）。ＣＰＨＤ组异常形态红细胞较对照组明显增多（Ｐ＜０．０５）。提示ＣＰＨＤ患者红细胞变形性下降与异常形态红细胞增多及红细胞膜流动性降低有关。
Erythrocyte deformability and erythrocyte membrane fluidity were measured in 23 healthy sudjects and 30 cases of chronic cor pulmonale patients.The shape of RBC was ob-served with scanning electronic microscope at the same time.The results showed that ery-throcyte filtration rate(EFR)of the patients and the control were 32.7±13.6 and 22.43±10.61,respectively(P<0.01).Erythrocyte membrane microviscosity(η)of the pa-tients and the control were 4.17±0.15 and 3.31±0.13.respectively(P<0.05).The number of abnormal shaped RBC of the patients increased significantly compared with that of the control.It was concluded that decreased erythrocyte defoimability in the acute exacerba-tion patients with chronic cor pulmonale was caused by both increase of the number of RBC with abnomal shape and decrease of erythrocyte membrane fluidity.
出处
《中日友好医院学报》
1996年第1期47-50,共4页
Journal of China-Japan Friendship Hospital
关键词
肺心病
荧光偏振
扫描电镜
红细胞变形性
pulmonalery heart disease
microscopy
electron scanning
fluores-cence polarization
