期刊文献+

Survivin、p53基因在脑胶质瘤组织的表达 被引量:1

暂未订购
导出
摘要 应用免疫组织化学方法,检测Survivin和p53基因在120例胶质瘤组织(WHOⅠ级40例,WHOⅡ级40例,WHOⅢ~Ⅳ级40例)和17例正常脑组织组织的表达。结果120例胶质瘤Survivin、突变型p53基因的阳性表达率为52.5%、45.8%,17例正常脑组织中Survivin、突变型p53基因不表达,差别有统计学意义(P〈0.05);随肿瘤分化程度降低,突变型p53和Survivin基因表达率逐渐升高(P〈0.05),Survivin与突变型p53基因的表达呈正相关(P〈0.01).
作者 宗强
出处 《山东医药》 CAS 北大核心 2006年第10期38-39,共2页 Shandong Medical Journal
  • 相关文献

参考文献3

  • 1Satoh K,Kaneko K,Hirota M,et al.Expression of survivin is correlated with cancer cell apoptosis and is involvedin the development of human pancreatic duct cell tumors[J].Cancer,2001,92(2):271-278.
  • 2Ialam A,Kageyama H,Takada N,et al.survivin initiates procaspase 3/p21 Fas-mediated cell death[J].Oncogene,2000,19(10):1346-1353.
  • 3Harris CC.Structure and function of the p53 tumor suppressor gene:clues for rational cancer therapeutic strategies[J].J Natl Cancer Inst,1996,88(20):1442-1445.

同被引文献8

  • 1Ambrosini G, Adida C, Altieti DC, et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma[ J]. Nat Med, 1997,3 (8) :917-921.
  • 2Kim HS, Shiraki K, Park SH. Expression of survivin in CIN and invasive squamous cell carcinoma of uterine cervix [ J]. Anticancer Res,2002,22(2A) :805-808.
  • 3Lee JP, Chang KH, Han JH, et al. Survivin, a nocel anti-apoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors[ J]. Int J Gynecol Cancer, 2005,15 ( 1 ) : 113-119.
  • 4Fields AC, Cotsonis G, Sexton D, et al. Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome[J]. Mod Pathol,2004,17( 11 ) :1378-1385.
  • 5Endo T, Abe S, Seidlar HB, et al. Expression of IAP family proteins in colon cancers from patients with different age groups[ J]. Cancer Immunol Immunother,2004,53 ( 9 ) :770-776.
  • 6Ikguchi M, Hirooka Y, Kaibara N. Quantitative analysis of apoptosis-related gene expression in hepatoceUular carcinoma[ J]. Cancer, 2002,95(9) :1938-1945.
  • 7Lu B, Mu Y, Cao C, et al. Survivin as a therapeutic target for radiation sensitization in lung cancer[ J]. Cancer Res, 2004,64 ( 8 ) : 2840-2845.
  • 8Zaffareni N, Pennati M, Colella G, et al. Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer[ J]. Cell Mol Life Sci, 2002,59 ( 8 ) : 1406-1412.

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部