摘要
目的评价依帕司他治疗糖尿病心脏自主神经病变疗效。方法糖尿病心脏病心脏自主神经病变患者接受依帕司他50mg,每日3次治疗,服用4周,运用24小时动态心电图检测患者在服用依帕司他前后心率变异性指标的变化,明确依帕司他治疗糖尿病心脏自主神经病变的疗效。结果心率变异性各项指标治疗4周后较治疗前有显著提高。自主神经症状明显好转。结论依帕司他治疗糖尿病心脏自主神经病变的疗效显著,可以改善患者心率变异性。
Objective To evaluate the effect of epalrestat on cardiac autonmic neuropathy in diabetes. Method Collection 50 patients with cardiac autonmic neuropathy in diabetes, taking 50mg epalrestat three times a clay at lest four weeks, measure heart rate variability （HRV） with 24-hours holter, Result The index of HRV significant improve after four-week treatment. Conclusion Epalrestat is Effective to treat cardiac autonmic neuropathy in diabetes and to improve HRV.
基金
2004年江苏省卫生厅临床药学科研课题(编号P200412)
