摘要
目的:观察抗胸腺细胞球蛋白(antithymocyte globulin,ATG)预防及治疗肾移植排斥反应的效果。方法:应用抗胸腺细胞球蛋白(ATG)预防或治疗各种肾移植排斥反应78例。结果:在38例预防性应用ATG者中,有3例发生急性排斥反应;14例难治性急性排斥患者中,12例经ATG治疗后逆转;15例肾小管坏死者中,有14例安全渡过急性肾小管坏死期;6例超急性排斥反应后再次移植中,经ATG治疗后,仍有3例再次发生超急性排斥;5例慢性排斥反应患者经ATG治疗后,连续观察3周,肾功能均未见明显好转。结论:ATG能够有效预防、控制急性排斥反应,并可逆转绝大多数难治性急性排斥反应,但不能预防超急性排斥反应及慢性排斥反应。
Objective：To evaluate the effects of antithymocyte globulin（ATG） on kidney transplantation rejection. Methods： ATG was administrated to 78 kidney graft recipients in order to prevent and treat the kidney transplantation rejection. Results： Acute rejection episodes were seen in 3 of 38 recipients under the condition of prophylactic administration of ATG, refractory rejection was reversed in 12 of 14 cases and renal function recovered in 14 of 15 cases with tubular necrosis. Though ATG was administered during re - transplantation to prevent hyper - acute rejection in fi recipients who had occurred hyper - acute rejection, 3 of fi ones occurred hyper - acute rejection again. After 5 cases with chronic rejection were treated with ATG, their renal function did not improve during three weeks monitored continuously. Conclusion： ATG is a potent immunosuppressant capable of reversing refractory acute rejection. Prophylactic administration of ATG can prevent acute rejection, but cannot prevent hyper - acute rejection and chronic rejection.
出处
《西南国防医药》
CAS
2006年第2期141-143,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
肾移植
排斥反应
抗胸腺细胞球蛋白
renal transplantation, rejection, antithymocyte globulin, prevention
