摘要
目的:观察复方甘草酸苷对模型动物肺纤维化的拮抗作用。方法:在SD大鼠气管内一次性注入博莱霉素A5制备肺纤维化大鼠模型,次日分别给予复方甘草酸苷和醋酸泼尼松龙(对照)治疗,测定、分析各组给药21d后肺组织脏器系数、肺组织病理、肺泡间隔面积、炎细胞面积、积分光密度改变情况。结果:与模型组比较,复方甘草酸苷组肺脏系数有减小趋势,肺组织病理改善,肺泡间隔面积明显减少(P<0.01),炎细胞面积总和、积分光密度显著降低(P<0.001);与醋酸泼尼松龙组比较无明显差异(P>0.05)。结论:复方甘草酸苷有拮抗模型动物肺纤维化的作用。
OBJECTIVE： To observe the antagonistic effect of compound glycyrrhizin on bleomycin A5-induced pulmonary fibrosis of rats, METHODS; Pulmonary fibrosis model was built by injecting bleomycin AS to tracheas of SD rats in one time, the next day, control groups were administered with compound glycyrrhizin and prednisolone acetate, 21 days after administration, organ coefficients, pathology, areas of alveolar septum, areas of the inflammatory cells and the integral pho todensity of the pulmonary tissues were detected and analyzed. RESULTS： As compared with the model group, the compound glycyrrhizin group had a diminished organ coefficient, ameliorated pathological change for pulmonary tissues and reduced areas of alveolar septum （P 〈 0.01）, and total area of the inflammatory cells and the integral photodensity decreased significantly （P 〈 0.001）, and there was no significant difference as compared with the compound glycyrrhizin group and the prednisolone acetate group （P 〉0.05）. CONCLUSION ： Compound glycyrrhizin has antagonistic effect on pulmonary fibrosis of model rats.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第7期497-499,共3页
China Pharmacy
关键词
复方甘草酸苷
大鼠
拮抗
肺纤维化
Compound glycyrrhizin
Rats
Antagonism
Pulmonary fibrosis
