摘要
目的：观察紫杉醇（PTX）联合小剂量顺铂（PDD）和持续静滴低剂量氟尿嘧啶（5-FU）治疗晚期胃癌的疗效和毒副反应.方法：全组35例患者中,贲门癌14例,胃体癌21例,应用PTX 90mg/m^2,第1、8天;5-FU 250mg/m^2持续24小时静滴,连用12天;PDD 6mg/（m^2·d）静滴,连用5天,间隔2天,再用5天,21天为1周期,平均用药3.06个周期.结果：全组35例均可评价,获得CR 3例,PR 17例,SD 10例,PD 5例,有效率（CR＋PR）为57.1%,肿瘤控制率（CR＋PR＋SD）为85.7%,中位TTP为9个月（1～32个月）,中位生存时间13个月（2～35个月）.主要不良反应为骨髓抑制、恶心呕吐和粘膜炎.结论：紫杉醇联合小剂量顺铂和持续静滴低剂量氟尿嘧啶治疗晚期胃癌患者疗效较好,不良反应可以耐受,值得深入研究.
Objective ：To evaluate the efficacy and toxicity of paclitaxel and low dose of cisplatin plus low dose of 5-fluorouracil continuous infusion combination chemotheay in the treatment of advanced gastric carcinoma. Methods：Thirty-five patients, including 14 cardiac cancer patients and 21 gastric body cancer patients, were treated with the following regimen, administered every 21 days, paclitaxel 90mg/m^2 by i.v. on d1 , d8, 5-FU 250mg/m^2 by 24h c. i. v. for 12 days and cisplatin 6mg/（ m^2 · d） by i. v for continous 5 days with 2 days interval within 12 days. All the patients received over two cycles of chemotherapy, median 3.06 cycles. Results：The overall response rate （ CR ＋ PR） was 57. 1%. TCR（ CR ＋ PR ＋ SD） was 85.7%. The median TIP was 9 months（ 1 - 32 months）. The MST was 13 months（2 - 35 months）. The major toxicity of this treatment were myelosuppression, nausea/vomiting and mucositis. Conelusion：Paclitaxel plus low dose of cisplatin and low dose of 5-fluorouracil continuous infusion combination chemotherapy in the treatment of advanced gastric carcinoma is effective and tolerable. It is worth studying.in the future.
出处
《临床肿瘤学杂志》
CAS
2006年第3期195-197,共3页
Chinese Clinical Oncology
关键词
晚期胃癌
紫杉醇
顺铂
氟尿嘧啶
持续静滴
化疗
Advanced gastric carcinoma
Paclitaxel
Cisplatin
5-iluorouracil
Continuous infusion
Chemotherapy
