摘要
目的:总结并分析随年龄增长人体骨代谢的特征,探讨随年龄增长骨骼的变化,重点探讨老年人,尤其闭经后妇女骨代谢的特征,为防治骨质疏松症提供科学依据。资料来源:应用计算机检索Medline1993-01/2003-12年龄增长与骨代谢文章。检索词为“Thebonemetabolism,Theagegrowth,”并限定文章语种为English。同时从图书馆人工检索1993-01/2003-12的日文资料中有关年龄增长与骨代谢相关的文章。资料选择:对资料进行初审,纳入标准:①关于随年龄增长骨骼的生理性变化特征、机制、影响因素。②对临床病例回顾性研究分析;排除重复性研究内容。资料提练:符合上述要求的文章21篇,排除14篇重复性研究。7篇符合纳入标准:其中3篇为研究性论著,2篇为诊断标准,2篇为教科书。资料综合:随年龄增长骨代谢变化很大,在生长期骨骼逐渐成熟,骨骼钙量逐渐增加。一般到20岁以后骨代谢处于动态平衡,40岁以后骨代谢呈负增长,骨骼钙量减少。骨代谢变化是随年龄增长最剧烈、变化量最大的一个参数。老年人,尤其是妇女闭经后骨质疏松发生率增长很快,除因老年人退行性变外,还与内分泌紊乱等多种因素相关,通过研究为防治骨质疏松症提供科学依据。结论:在了解年龄增长与骨代谢关系的基础上,认识到防治骨质疏是可能的,主要是建立健康的生活方式,注意营养全面,摄入足量的含钙高的食物。
OBJECTIVE： To summarize and analyze the characteristics of bone metabolism with the growing of age, and explore the skeletal change with the increase of age especially in the elderly people and the females of postmenopause so as to provide scientific evidence for the prevention and treatment of osteoporosis.
DATA SOURCES： Literatures about age growth and bone metabolism were computer-searched in Medline database published from January 1993 to December 2003, with the key words of ＂The bone metabolism,The age growth＂ in English. Meanwhile, it was also manually searched in library published between January 1993 and December 2003 for related articles in Japanese.
STUDY SELECTION： After the primary search, inclusive criteria：① Physiological characteristics, mechanism and influenced factors of the bone metabolism with the growing of age. ②Analysis of retrospective study was done in clinical cases. Repetitive experimental studies were excluded.
DATA EXTRACTION： Totally 21 papers were accorded with the abovementioned requirements, and 14 repetitive studies were excluded. Seven articles were. referred to the inclusive criteria, in which 3 articles were researehful; 2 articles were diagnostic criterions; 2 articles were textbook.
DATA SYNTHESIS： Bone metabolism changed greatly; skeleton became mature gradually and bone calcium increased with the age growth. Bone metabolism reached homeostasis after 20 years, and then appeared negative growth after 40 years and bone calcium decreased. Bone metabolism was the most intense and variable parameter with the growing of age. The rate of osteoporosis increased greatly in elderly people, especially in the females of postemenopanse, which might be related to endocrine disorder and so on, except degeneration in elderly people. Studying these could provide scientific evidence for the prevention and treatment of osteoporosis.
CONCLUSION： On the basis of understanding the relationship between age growth and bone metabolism, we realize that osteoporosis may be prevented mainly by means of establishing healthy life-style, full nutrition and high calcium ingestion.
出处
《中国临床康复》
CSCD
北大核心
2006年第16期190-192,共3页
Chinese Journal of Clinical Rehabilitation
