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细胞间缝隙连接通讯改变在神经系统疾病中的应用 被引量：3

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摘要 细胞间缝隙连接通讯（gap junctional intercellular communication，GJIC）概念的提出已达40年，随着划痕标记染料示踪（scrape—loading and dye transfer，SLDT）技术和激光扫描共聚焦显微镜下荧光淬灭后恢复（fluorescence redistribution after photobleacing，FRAP）技术的创立，使得近10余年来各学科关于细胞间缝隙连接通讯的研究快速发展，业已成为生命科学的研究热点之一。
作者 只达石
机构地区 天津医科大学总医院
出处 《中国现代神经疾病杂志》 CAS 2006年第2期77-81,共5页 Chinese Journal of Contemporary Neurology and Neurosurgery
关键词 细胞间缝隙连接通讯 神经系统疾病 荧光淬灭后恢复 染料示踪 划痕标记 显微镜下 激光扫描 生命科学 and 共聚焦
分类号 R735.34 [医药卫生—肿瘤] R741 [医药卫生—神经病学与精神病学]
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参考文献24

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  • 4[6]Mesnil M.Gap junctions and cancer:implications and perspectives.Med Sci (Paris),2004,20:197-206.
  • 5[7]Ehrlich HP,Diez T.Role for gap junctional intercellular communications in wound repair.Wound Repair Regen,2003,11:481-489.
  • 6[8]Kielian T,Esen N.Effects of neuroinflammation on glia-glia gap junctional intercellular communication:a perspective.Neurochem Int,2004,45:429-436.
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二级参考文献22

  • 1邓方,饶明俐,冯加纯.星形胶质细胞缝隙连接与缺血性脑卒中[J].中风与神经疾病杂志,2004,21(5):469-470. 被引量：2
  • 2[1]EL-Fouly MH,Trosko JE,Chang CC.Scrape-loading and dye transfer:a rapid and simple technique to study gap junctional intercellular communication.Exp Cell Res,1987,168:422-430.
  • 3[5]Oh SY,Madhukar BV,Trosko JE.Inhibition of gap junction blockage by palmitoyl camitine and TMB-8 in a rat liver epithelial cell line.Carcinogenesis,1988,9:135-139.
  • 4[7]Cotrina ML,Kang J,Lin JH,et al.A strocytic gap junctions remain open during ischemic conditions.J Neurosci,1998,18:2520-2537.
  • 5[8]Martinez AD,Saez JC.Regulation of astrocyte gap junctions by hypoxia-reoxygenation.Brain Res Brain Res Rev,2000,32:250-258.
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  • 7[11]Budd SL,Lipton SA.Calcium tsunam is:do astrocytes tyansmit cell death messages via gap junctions during ischemia.Nat Neurosci,1998,1:431-432.
  • 8Christ GJ, Spray DC, Brink PR, et al. Gap junctions in vascular tissues. Circ Res , 1996, 79:631-646.
  • 9Gioia AE,Richard PW,Bijan B,et al. Evaluation of the efficacy of intrathecal nimodipine in canine models of chronic cerebral vasospasm. J Neuro,1985, 62:721-728.
  • 10Megyesi JF, Vollrath B, Cook DA, et al. In vivo animal models of cerebral vasospasm: a review. Neurosurgery, 2000, 46:448460.

共引文献20

同被引文献38

  • 1闫华,只达石,黄慧玲,张文治,苏心,刘锐.低温对大鼠胶质细胞间缝隙连接通讯功能的影响[J].中国现代神经疾病杂志,2006,6(1):47-51. 被引量：5
  • 2闫华,只达石,刘锐.荧光显微镜划痕标记染料示踪技术的改进[J].中国现代神经疾病杂志,2006,6(2):123-123. 被引量：3
  • 3只达石.细胞间缝隙连接通讯与中枢神经系统创伤[J].中华创伤杂志,2006,22(12):946-948. 被引量：5
  • 4Ehrlich HP,Diez T.Role for gap junctional intercellular communications in wound repair.Wound Repair Regen,2003,11:481 -489.
  • 5Kielian T,Esen N.Effects of neuroinflammation on glia-glia gap junctional intercellular communication:a perspective.Neurochem Int,2004,45:429-436.
  • 6Lee IH,Lindqvist E,Kiehn O,et al.Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury.J Comp Neurol,2005,489:1-10.
  • 7Cotrina ML,Kang J,Lin JH,et al.Astrocytic gap junctions remain open during ischemic conditions.J Neurosci,1998,18:2520-2537.
  • 8Martinez AD,Sarez JC.Regulation of astrocyte gap junctions by hypoxia-reoxygenation.Brain Res Rev,2000,32:250 -258.
  • 9Rami A,Volkmann T,Winckler J.Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia.Exp Neurol,2001,170:297 -304.
  • 10Nakase T,Fushiki S,Naus CC.Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia.Stroke,2003,34:1987-1993.

引证文献3

二级引证文献8

中国现代神经疾病杂志
2006年 第2期

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