摘要
为揭示生长抑素在癫痫发生发展中的作用及其与癫痫患儿行为之间的关系，采用放射免疫法测定海人酸（ＫＡ）诱发癫痫动物模型脑组织与血浆生长抑素放射免疫活性（ＳＬＩ）。对２２例癫痫患儿进行血浆ＳＬＩ的检测和事件相关诱发电位的测查，并用Ａｃｈｅｎｂａｃｈ儿童行为量表进行评价。结果显示，动物额叶皮层内ＳＬＩ在注射ＫＡ后７天显著增高，可能与ＫＡ诱发动物癫痫敏感性增高有关。癫痫患儿血浆ＳＬＩ显著高于正常对照组，其行为异常发生率为４０．９％，Ｎ１００、Ｐ３００潜伏期均明显延长，血浆ＳＬＩ与攻击行为、多动行为呈显著负相关。提示癫痫发作后血浆ＳＬＩ的变化既反映了发作后生长抑素能神经元功能的改变。
Inordertoinvestigatetheroleofsomatostatinanditsrelationtothebehaviorinchil-drenwithepilepsy,wemeasuredsomatostatin-likeimmunoreactivity(SLI)inbraintisueandplasmaofkainicacid(KA)inducedmodel,andSLIinplasmafrom22childrensuferingfromepilepsywithRIA.Simultaneously,weexaminedtheireventrelatedpotentialsandassessedtheirbehaviorwiththeAchenbachChildBehaviorChecklist.TheresultsshowedthatsevendaysafterKAinjection,asig-nificantelevationofSLIwasfoundinbilateralfrontalcortex,whichwasprobablyrelatedtothein-creasedseizuresusceptibilityinducedbyKA.PlasmaSLIofepilepsywasmarkedlyincreasedcom-paredwithcontrols.About40.9%childrenwithepilepsyhadbehaviordisturbance.ThelatenciesofN100andP300wereobviouslyprolongedinepilepsy.Throughstepwiseregresionanalysis,wefoundthatSLIinplasmahadasignificantreversecorelationwithaggresivebehaviorandhyperactivity.TheseresultsindicatethatthechangeofplasmaSLIreflectsthefunctionalalterationofsomatostatinneuronafterseizure,andmayprovideabiochemicalbasisforbehaviorproblemandcognitivedeficien-cyinepilepsy.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1996年第4期264-266,共3页
Chinese Journal of Pediatrics
