摘要
为探讨丙谷胺辅助治疗对提高贲门腺癌切除术后生存率的作用。作者对行近侧胃大部分切除术的７３例贲门腺癌病人，术后持续餐前服用丙谷胺，每天３次，每次０．４ｇ。对照组６２例为单纯手术治疗。经３年以上随诊，结果见丙谷胺组１、２、３年生存率分别为８７．７％（６４／７３）、７５．３％（５５／７３）、４３．８％（３２／７３），明显高于对照组（Ｐ＜０．０１和Ｐ＜０．００１）。作者认为丙谷胺服用方便，无明显毒副作用，术后长期服用可提高贲门癌切除术后的生存率。
Objective :To study actions of proglumide as an adjuvant treatment to raise the postoperative long-term survival rate of patients with cardiac adenocarcinoma. Method :Proglumide was administered after proximal subtotal gastrectomy in 73 patients(proglumide group) with cardiac adenocarcinoma. The administration of proglumide 0. 4g t.i.d. preprandially was maintained. In the control group,62 patients received operation only. Follow-up lasted for more than 3 years. Result: In the proglumide group,the 1-,2- and 3-year survival rates were 87.7%(64/73),75. 3%(55/73) and 43. 8%(32/73) respectively,and were obviously higher than the control group(P<0. 01 and P<0. 001). Conclusion:The proglumide is convenient to use with no obvious toxic side effect,and prolonged postoperative administration of proglumide can raise the long-term survival rate of patieats after resection of cardiac carcinoma.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1996年第4期214-216,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
