摘要
应用免疫组化法于石蜡切片检测甲状腺肿瘤ｃ－ｅｒｂ－Ｂ２癌基因产物Ｐ１８５和ｃ－ｒａｓ基因产物Ｐ２１的表达。结果显示：３３例甲状腺癌Ｐ１８５和Ｐ２１的阳性率分别为６０．６％（２０／３３）和１００％（３３／３３）。３２例良性甲状腺病变Ｐ１８５和Ｐ２１的阳性率分别是２５％（８／３２）和５６．３％（１８／３２）。良性组与恶性组比较，两种基因产物的表达差异均非常显著，说明甲状腺癌的发生发展与ｃ－ｅｒｂ－Ｂ２和ｒａｓ癌基因的活化，产生过多的基因产物有关。Ｐ１８５和Ｐ２１在甲状腺癌的表达同时阳性者占６０．６％，提示两种癌基因蛋白在甲状腺癌的发生发展中具有一定的相关性。
The expression of P185 and P21 oncogene protein in patients withvarious benign diseases and neoplasms of the thyroid were examined immunocytochemically.It was found that the positive expression of P185 and P21 oncogeneProtein in thyroid cancer were observed in 60. 6%(20/33) and 100%(33/33) respectively,while they were 25%(8/32) and 56.3%(18/32) respectively in benignthyroid diseases.This result suggests that the development of thyroid cancer mightbe closely related to over activation of c-erbB-2 and ras oncogene with over expressof gene productions.Both P185 and P21 positive expression occurred in 60. 6% ofthyroid cancers and 4 cases of Hurthle cell adenoma. A fact implies that there issome relationship between P185,P21 and the development of thyroid carcinomas.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1996年第7期512-515,共4页
Chinese Journal of Clinical Oncology
