摘要
目的分析我国大陆恶性高热(MH)病例的临床资料,探讨诊断和治疗中应注意的问题。方法检索中国生物医学文献数据库,收集1978年1月至2004年3月报道的MH病例34例,分析其流行病学特征、发病特点、临床表现、治疗及转归。结果我国大陆报道的MH病例以青少年居多,男性多于女性,集中在口腔科手术(尤其是唇腭裂修补术)、骨科手术和小儿外科手术(尤其是先天畸形矫治术),典型的临床表现为突然发生的高碳酸血症、体温急剧升高和骨骼肌僵直等。诊断上主要是根据临床表现,尚未建立骨骼肌体外收缩试验方法,治疗上主要是对症处理,缺乏特效药物(丹曲林)。结论近几年我国大陆MH病例逐渐增加,应加强对MH发病机制的研究,尽快建立MH的实验诊断标准,增强预防、诊断和治疗MH的能力。
Objective To analyze the clinical data and features of malignant hyperthermia （MH） in China's Mainland and address the problems associated with diagnosis and treatment of MH. Methods Thirty-four cases of MH which occurred in China's Mainland from January 1978 to March 2004 were reviewed and analyzed. Results MH syndrome occurred more frequently in adolescents with more males than females and developed very often during oral surgery （ especially cleft lip and palate repair）, orthopedic surgery and pediatric surgery for congenital anomalies. The main clinical manifestations included hypercapnia, high body temperature and muscle rigidity. In most cases diagnosis of MH was made based on clinical manifestations only without＇in vitro contracture test＇ the golden standard for diagnosis of MH. No specific treatment was available and no epidemiological study was done. Conclusion The report of MH has been increasing recently in China's Mainland. Studies on MH should be intensified by establishing the standard of laboratory diagnosis of MH.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2006年第2期107-109,共3页
Chinese Journal of Anesthesiology
关键词
恶性高热
手术中并发症
回顾性研究
Malignant hyperthermia
Intraoperafive complications
Retrospective studies
