摘要
目的:探讨乙肝病毒基因产物HBsAg,HBcAg,HBxAg在乙型肝炎相关性肝癌中的表达及其在肝细胞癌变中的作用。方法:采用组织芯片技术和免疫组织化学染色方法对152例乙型肝炎相关肝细胞肝癌组织、78例乙型肝炎后肝硬化组织中HBsAg,HBcAg,HBxAg的表达进行检测。结果:和乙型肝炎后肝硬化相比,在乙型肝炎相关性肝癌组织中HBsAg表达显著降低(P=0.000);HBcAg表达显著增高(P=0.000);HBxAg显著增高(P=0.005)。结论:乙肝病毒抗原成分HBcAg,HBxAg参与乙型肝炎相关性肝癌的发生。
Objective： To study the expression of the products of HBV genome, HBsAg,HBcAg and HBxAg in hepatitis-related carcinoma. Methods： A total of 152 cases of carcinomas and 78 cases of posthepatitis liver cirrhosis were stained by immunohistochemical methods combined with tissue chip to detect the expression of the HBV antigen HBsAg, HBcAg, HBxAg. Results： The expression of HBcAg, HBxAg was significantly higher in carcinoma than that in cirrhosis （P=0.000 and P=0.005 respectively）. The expression of HBsAg was significantly lower in carcinoma than that in cirrhosis （P=0.000）. Conclusion： HBcAg and HBxAg take part in the carcinogensis of hepatitis-related hepatocellular carcinoma.
出处
《天津医科大学学报》
2006年第1期4-6,共3页
Journal of Tianjin Medical University
基金
天津市自然科学基金资助(023616511)
天津医科大学科研基金资助(2003KY28)
