摘要
目的：在山区血吸虫病流行区观察蒿甲醚（Ａｒｔ）口服预防血吸虫感染的效果。方法：选择云南省大理市洱源县有血吸虫病流行的３个村为试点。该试点的钉螺感染率为８．７％，感染螺平均密度为０．２２１９只／０．１１ｍ２，人群感染率为１６．４％。选择４－６０岁经常接触疫水的村民，随机配对分为Ａｒｔ组和对照组，经查病后，血吸虫卵阳性者１次口服吡喹酮５０ｍｇ／ｋｇ，阴性者服４０ｍｇ／ｋｇ。受试村民于５月下旬接触疫水半个月后口服第１剂Ａｒｔ６ｍｇ／ｋｇ，以后每半个月重复给药１次，共服药４次，对照组口服相同剂型的安慰剂（淀粉），末次给药后２５－３２ｄ作粪检复查。结果：Ａｒｔ组３０７人的粪检阳性率为４．２％，对照组３０６人的为１５％，差异显著。此外，对照组有４例急性血吸虫病发生，而Ａｒｔ组则无。结论：口服蒿甲醚，对山区感染较重的血吸虫病流行区有较好的预防效果，并可防止急性血吸虫病。
AIM: To study the preventive effect of oral artemether (Art) in a schistosomiasis endemic area of mountainous type. METHOD:Three villages of Eryuan County, Dali City, Yunnan Province were selected as the pilot of the study where the infection rate of the snail was 8 7% with a mean density of infected snail of 0 2219/0 11 m 2 and the infection rate of the residents was 16 4%. Residents aged 4-60 in the pilot were selected for study and allocated randomly to Art group and the control group. One month before the performance of prevention with Art, stool examination was carried out in all residents and praziquantel was given orally to the egg negative residents and egg positive residents at a single dose of 40 mg/kg and 50 mg/kg, respectively. In Art group, the first dose of 6 mg/kg was given to the residents in the late May, i.e., about 15 days after contacting with infested water, followed by repeated dosing every 15 days for 3 times. Placebo (starch) was given to the residents in the control group at the same time as in Art group. The efficacy was evaluated by stool examination 25-32 days after the last medication. RESULTS: In Art group 13 out of 307 residents examined revealed stool positive with an infection rate of 4 2%, while in the control group 46 out of 306 residents examined showed stool positive with an infection rate of 15%. Meantime, the egg per gram of feces (EPG) determined with the Kato Katz method was 49 8±28 6 in the control group and 28 8±10 7 in Art group. The differences in infection rates and EPG(s) between the two groups were statistically significant. Furthermore, 4 cases of acute schistosomiasis were seen in the control group, but none was found in Art group. CONCLUSION: In schistosomiasis endemic area of mountainous type, oral Art exhibited a promising preventive effect on both reducing infection rate and controlling acute schistosomiasis.
出处
《中国寄生虫学与寄生虫病杂志》
CSCD
北大核心
1996年第1期11-14,共4页
Chinese Journal of Parasitology and Parasitic Diseases
关键词
日本血吸虫
血吸虫病
预防
蒿甲醚
云南
Schistosomiasis
acute schistosomiasis
prevention
infection rate
artemether
