摘要
本文观察了一氧化氮在１０ｄ龄新生大鼠败血症中的含量变化，并探讨了其抑制剂美蓝或／和地塞米松的治疗作用。结果表明：新生大鼠血浆一氧化氮水平于细菌注射后６ｈ开始明显升高（Ｐ＜０．０５）。用美蓝或／和地塞米松治疗可显著改善代谢紊乱指标低葡萄糖血症和高乳酸血症，降低模拟病情严重程度的丧失疼痛反对发生率以及延长存活时间（Ｐ＜０．０５）；地塞米松治疗还可明显降低２４ｈ病死率（Ｐ＜０．０５）．一氧化氮及其抑制剂的临床应用前景值得重视。
In a newborn rat model of sepsis,the changes of nitric oxide levels and thetherapeutic effects of methylene blue or/and dexamethasone were investigated.The resultsrevealed that plasma nitric oxide levels were elevated sinee 6h(P<0.05)after bacterial chal-lenge。The treatment with methylene blue or/and dexamethasone was found to blunt hypoglyeenlla and hyperlactieemia (P< 0.05 respectively),to reduce the oeeurrence rate of loss of re-sponse to pain(P<0.05 respectively),and prolong the survivaI time(P< 0.05,respectively).Moreover,dexamethasone therapy was shown to decrease the 24h mortality rate comparedwith the controls(P<0.05).These results suggested that the clinical value of nitric oxide andits inhibitors need to be further studied.
出处
《中国病理生理杂志》
CSCD
北大核心
1996年第4期387-391,共5页
Chinese Journal of Pathophysiology
关键词
一氧化氮
败血症
亚甲蓝
地塞米松
Nitric oxide.Septicemia.Methylene blue.Dexamethasone
