摘要
PADAM原称男子更年期综合征,同义词有“ADAM”或“Late hypogonadism”。男子的血清睾酮水平在40岁以后逐渐下降,性激素结合球蛋白水平逐渐升高,70岁时血清总睾酮水平下降了约30%,游离睾酮下降了约40%。PADAM的诊断依据血清睾酮水平降低和出现相关的症状。PADAM的基本治疗是补充睾酮,可以口服或肌注十一酸睾酮,或使用睾酮皮肤贴剂或凝胶剂。睾酮补充治疗可以改善性功能、增加瘦体量、减少体脂、促进骨质形成、改善认知功能、降低罹患2型糖尿病和心血管疾病的危险。治疗过程中应定期监测红细胞、肝功能、前列腺指检和PSA。
The old term of PADAM is ＂male climacteric＂ or ＂andropause＂ with the synoym of ＂ADAM＂ or ＂ late hypogonadism＂. The serum level of testosterone in male progressives declined after the age of 40 while SHBG increased. At age of 70, around 30 % of the total testosterone and 40 % of the free testosterone lost. The diagnosis of PADAM is based on the low serum level of androgen and the presence of related symptoms. The basic treatment for PADAM is androgen supplementation（TST）. Testosterone undecanoate is a common agent for this purpose. The skin patch or gel of testosterone are also recommended. The benefits of TST are improvement of sexual function, increase of lean body mass, decrease of body fat, enhancement of bone formation and cognition function, and decreased the risks of suffering from type 2 diabetes and cardiovascular disease. On the way of TST, it is necessary to monitor erythrocytes, liver function, prostate digital examination and serum PSA regularly.
出处
《基础医学与临床》
CSCD
北大核心
2006年第3期231-237,共7页
Basic and Clinical Medicine
关键词
中老年男子
部分雄激素缺乏
诊断
治疗
aging male
partial androgen deficiency
diagnosis
treatment
