摘要
观察了茶碱等７种临床常用的口服缓释制剂在不同时间及ｐＨ条件下的溶出情况。可归纳为３类，一为在酸碱住条件下溶出量均按一定比例随时间延长而增加；一为初期有较大的溶出量，以后增长较少而趋平稳；一为受酸碱性影响，在碱性介质中能很快全部溶出。
The dissolution of seven sustained release preparations for oral administration observed in different PH media and times.In three of them,the dissolution increased progressively with time.In other three preparations,there was a high dissolution rate at initial stage.Another one showed much irregular to basic medium.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1996年第6期250-252,共3页
Chinese Journal of Pharmaceuticals
关键词
缓释制剂
溶出度
质量控制
slow release preparation,dissolution,quality control
