摘要
AIM： To evaluate the reproducibility of a modified 13^C breath test-based measurement of solid phase gastric emptying （GE） within the frames of a simple-repeated measure study protocol. METHODS： Twelve healthy subjects （6 females and 6 males, mean age 24.9＋0.7 years） were recruited to undergo three identical GE examinations. In six subjects the first two examinations were performed 2 d apart, and the third session was carried out at a median interval of 19.5 d （range 18 - 20 d） from the second one. In another six subjects the first two measurements were taken 20 d apart （median, range： 17-23 d）, whereas the third session took place 2 d after the second one. Probes of expiratory air collected before and during six hours after intake of a solid meal （378 kcal） labelled with 75 μL （68 mg） 13^C-octanoic acid, were measured for 13^CO2 enrichment with the nondispersive isotopeselective infrared spectrometry NDIRS apparatus. RESULTS： Taking coefficients of variation for paired examinations into account, the short-term reproducibility of the GE measurement was slightly but not significantly better than the medium-term one： 7.7% and 11.2% for the lag phase （T-Lag）, 7.3% and 10.9% for the gastric half emptying time （T1/2）. The least differences in GE parameters detectable at P= 0.05 level in the 12 paired examinations were 9.6 and 15.6 min for T-Lag, 11.6 and 19.7 min for T1/2 by a two-day or two to three-week time gap, respectively CONCLUSION： The low-cost modification of the breath test involving a lower dose of 13^C-octanoic acid and NDIRS, renders good short- and medium-term reproducibility, as well as sensitivity of the measurement of gastric emptying of solids.
瞄准：在一个简单重复的措施学习协议的框架以内评估固体的基于测试的测量分阶段执行胃的倒空的修改 13C 呼吸(GE ) 的重制度。方法：12 个健康题目(6 女性和 6 男性，意味着年龄 24.9+/-0.7 年) 被招募经历三相同 GE 考试。在六个题目，开始的二考试被执行 2 d 分开，并且第三个会议从第二个在 19.5 d (范围 18-20 d ) 的中部的间隔被执行。在六个题目，开始的二大小被拆开 20 d (中部，范围：17-23 d ) ，而第三个会议发生了在第二以后的 2 d。在稳固的饭(378 千卡) 的吸入以后收集在前并且在六个小时期间的吐气的空气的探针用 75 microL (68 mg ) 标记 13C-octanoic 酸，与非散的同位素选择的红外线的分光术 NDIRS 仪器为 13CO2 丰富被测量。结果：为配对的考试考虑变化的系数， GE 测量的短期的重制度比中期的稍微然而并非显著地好：7.7% 和 11.2% 为迟滞期(T 落后) ， 7.3% 和 10.9% 为倒空时间(T1/2 ) 的胃的一半。在在在 12 配对的考试的 P=0.05 水平可检测的 GE 参数的最少的差别是为 T 落后的 9.6 和 15.6 min，为由到三星期的时间的一两个 two-day 的 T1/2 的 11.6 和 19.7 min 分别地豁开。结论：呼吸的便宜修正测试包含 13C-octanoic 酸和 NDIRS 的更低的剂量，显示固体的胃的倒空的测量的好短期、中期的重制度，以及敏感。
基金
Supported by a research grant(3 P05D 054 24)from the Ministry of Scientific Research and Information Technology(formerly:State Committee For Scientific Research)of the Republic of Poland-contract #0617/P05/2003/24
