摘要
通过重氮偶合、还原环化和酯化反应合成了5-氯-2-[2-羟基-3-叔丁基-5-（3-丙酸甲酯基）苯基]-2H-苯并三唑，并进行了工业放大实验，收率53．0％～55．O％。偶合反应时，以十二烷基苯磺酸钠为乳化试剂，pH=5～8，收率为73．7％；采用n（偶合物）：n（保险粉）：n（NaOH）=1.0：3．5：15．8进行还原反应，收率81．0％。用MS和。HNMR谱图表征了产物的结构，测定了产物的紫外吸收和透光率。
5-Chloro 2 [ 2-hydroxy-3-tert-butyl-5 -（2-methoxycarbonylethyl） phenyl]-2H-benzotriazole was synthesized through four steps including diazotization, coupling, hydrogenation and esterifica- tion. The yield in laboratory and the scaled up process was 56.2% and 53.0%- 55.0%, respectively.In the process of coupling, at pH=5 -8 with sodium dodecyl benzenesulfonate as emulsification, the yield was 73.7%. In the process of hydrogenation, with the optimal ratio of n（dye） ： n（rongalite） ： n （sodium hydroxide） =1.0 ： 3.5 ： 15.8, the yield was 81.0%. The product was characterized by MS and ^1 H NMR. The abilities of UV-absorption and permeating light of the product were measured.
出处
《精细石油化工》
CAS
CSCD
北大核心
2006年第2期31-34,共4页
Speciality Petrochemicals
关键词
苯并三唑
紫外线吸收剂
重氮偶合
还原
酯化
benzotriazole
ultraviolet light absorber
diazotization-coupling
hydrogenation
esterification
