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PECAM-1单核苷酸多态性与中国人群冠心病的相关性 被引量：4

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摘要 目的研究血小板内皮细胞黏附分子1(PECAM1)基因第2外显子单核苷酸多态性(SNP)与中国人群冠心病的相关性。方法选择90例冠心病患者及年龄、性别相匹配的115例正常对照组,采用聚合酶链反应限制性片段长度多态性(PCRRFLP)方法检测PECAM1基因型,比较两组基因型及等位基因频率分布。结果冠心病组V/V基因型频率(40.00%)明显高于对照组(23.48%)(P<0.05);与对照组相比,冠心病组V等位基因频率(58.89%)明显升高,L等位基因频率(41.11%)明显降低(P<0.05);吸烟使V/V基因型者冠心病发病危险度由2.17上升至3.50(P<0.05)。结论PECAM1基因第2外显子SNP与中国人群冠心病相关,V/V基因型可能是中国人群冠心病的遗传易患因子。
作者 潘闽 蒋文平 刘志华 杨向军 朱健华 袁瑾 吴翔
机构地区 苏州大学附属第一医院心内科 南通大学附属医院心内科
出处 《江苏医药》 CAS CSCD 北大核心 2006年第4期366-367,共2页 Jiangsu Medical Journal
关键词 血小板内皮细胞黏附分子-1 基因 单核苷酸多态性 冠状动脉疾病
分类号 R392-33 [医药卫生—免疫学] R364.5 [医药卫生—病理学]
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参考文献4

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同被引文献37

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引证文献4

二级引证文献18

江苏医药
2006年 第4期

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