摘要
目的:探讨子宫内膜癌组织中pten、p53蛋白表达,以及与子宫内膜癌发生、发展及预后的关系。方法:应用免疫组化SP法检测20例子宫内膜癌组织中pten、p53蛋白的表达。结果:子宫内膜癌组织中pten蛋白的失表达主要局限于子宫内膜样腺癌,占60%,5例浆液性癌中则未见pten的失表达,pten失表达在这两组肿瘤间的差异有显著性(P=0.006),p53蛋白过表达在子宫内膜样腺癌中占26.7%,在浆液性癌中为80%,两组间差异有极显著性(P=0.001)。结论:pten、p53蛋白的表达与子宫内膜癌的发生相关。用免疫组化法检测pten的表达缺失及p53的过表达是诊断子宫内膜癌及癌前病变的有价值的分子标记物。
Objective：To investigate the relationship of the expressions of protein pten and protein p53 in the occurrence, development and prognosis of endometrial carcinoma （EC）. Methods：The expressions of protein pten and protein p53 in 20 endometrial adenocareinomas were examined by SP immunohistochemical method. Results： In the endometrial carcinoma tela,the lack of expression of protein pten existed in endometrioid adenocareinoma mainly,which accounted for 60 per cent. In 5 serous carcinoma cases, however, the lack of expression of protein pten was not seen. The lack of expressi0n of protein pten was significant difference between the two groups （P=0.006）.The over-expression of protein p53 covered 26.7 per cent in endometrioid adenocareinoma while covered 80 per cent in serous careinoma.The differences between the two groups were significant （P=0.001）. Conclusion：The expressions of protein pten and protein p53 are relevant to the occurrence of endometrial carcinoma. The expression loss of protein pten and over-expression of protein p53 the detected by SP immunohistochemical method are likely to be valuable labelled molecules used to diagnose endometrial carcinoma and its precancerous lesion.
出处
《现代医药卫生》
2006年第7期961-962,共2页
Journal of Modern Medicine & Health
