摘要
分别测定２０名健康人、２９例慢性肺心病患者的急性期和缓解或血清维生素Ｅ（ＶＥ）、血浆ＬＰＯ、ＴＸＡ２、ＰＧ－Ｉ２、ＧＳＨ－Ｐｘ值，进行对比，结果急性或血ＶＥ含量减低，缓解期上升．ＧＳＨ－Ｐｘ、ＧＳＨ－Ｐｘ／ＬＰＯ比值与ＶＥ呈正相关，ＬＰＯ和ＴＸＢ２／６－Ｋ－ＰＧＦ１ａ比值与ＶＥ均呈负相关．提示心病急性期机体抗氧化潜力下降，并有ＴＸＡ２／ＰＧＩ２失衡，维持血ＶＥ正常水平有利于提高机体抗氧化能力和维持ＴＸＡ２／ＰＧＩ２平衡．
Serum vitamin E, glutathione peroxidase (GSH-Px) of the whole blood,plasma lipid peroxide (LPO), thromboxane A2 (TXA2)and prostaglandin I2 (PGI2) were measured separately in 29 patients with chronic cor pulmonale during exacerbation and relaxation.The results showed that VE decreased during exacerbation and returnted to normal level during relaxation. VE was positively correlated with GSH-Px, GSH/LPO, and negatively correlatively with LPO, TXB2/6-K-PGF1a.These results suggested that there are decreased ability of antioxidation and TXA2/PGI2 imbalance during the exacerbation in corpulmonale; maintaining the normal level of VE may be helpful to restore the ability of antioxidation and keep TXA2/PGI2 balance.
出处
《铁道医学》
1996年第2期80-81,共2页
Railway Medical Journal
关键词
肺心病
GSH-PX
血栓素A2
维生素E
测定
chronic cor pulmonale lipid peroxiade glulathione perxidase thromboxane A2 prostaglandin vitamin E
