期刊文献+

白介素4受体基因多态性与变应性疾病 被引量:4

原文传递
导出
摘要 变应性疾病是一类具有遗传易感性的多基因遗传病,受到多个基因的遗传控制。对其发病基因的研究是近年来的热点。本文就已发现的IL-4R上的多个基因多态性位点与变应性疾病的相关联系作一综述,为进一步揭示疾病的遗传学背景和发病机制以及为今后基因诊断和治疗提供线索。
出处 《国际耳鼻咽喉头颈外科杂志》 2006年第2期83-86,共4页 International Journal of Otolaryngology-Head and Neck Surgery
  • 相关文献

参考文献23

  • 1Romagnani S. Atopie allergy and other hypersensitivities interactions between genetic susceptibility, innocuous and/or microbial antigens and the immune system. Curr Opin Immunol, 1997, 9(6) : 773-775.
  • 2Marsh DG, Neely JD, Breazeale DR, et al. Linkage analysis of IL-4 and other chromosome 5q31.1 markers and total serum immunaglobulin concentrations. Science, 1994, 264(3) : 1152-1156.
  • 3Sandford AJ, Chagani T, Zhu S, et al. Polymorphism in the IL-4 IL-4Rα and FeERIβ genes and asthma severity. J Allergy Clin Jmmunol,2002, 106( ⅠPt 1) : 135-140.
  • 4Deichmann KA, Heinzmann A, Forster J, et al. Linkage and allelic association of atopy and makers flanking the IL-4 receptor gene. Clin Exp Allergy, 1998, 28(2) : 151-155.
  • 5Idzerda RL, March C J, Mosley B, et al. Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor super-family. J Exp Med, 1990, 171(3) : 861-873.
  • 6Deichmann K, Bardutzky J, Forster J, et al. Common polymorphisms in the coding part of the IL-4 receptor gene. Biochemical and Biophysical Research Communication, 1997, 231 (3) : 696-697.
  • 7Ober C, Willadsen SA, Tsalenko A, et al, Variation in the interleukin 4 receptor alpha gene coders susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet, 2000, 66 ( 2 ) :517-526,
  • 8Nagarkatti R, Ghosh B. Identification of single-nucleotide and repeat polymorphisms in two candidate genes, intedeukin 4 receptor ( IL-4Rα) and signal transducer and activator of transcription protein 6( STAT6), for Th2-mediated diseases. J Hum Genet, 2002, 47 (12) :684-687.
  • 9Mitsuyasu H, Izuhara K, Mao XQ, et al. IleSOVal variant of IL-4R alpha upregulates IgE synthesis and associates with atopic asthma. J Nat Genet, 1998, 19 (2) : 119-120.
  • 10Mitsuyasu H, Yanagihara Y, Mao XQ, et al. Cutting edge: dominant effect of Ile50Val variant of the human interleukin-4 receptor alpha chain in IgE synthesis. J Immunology, 1999, 162(3) : 1227-1231.

同被引文献35

引证文献4

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部