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线粒体DNA异常与头颈肿瘤 被引量：1

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摘要 线粒体是细胞进行氧化磷酸化反应的主要场所。多项研究显示肿瘤线粒体DNA的突变率高。头颈部恶性肿瘤是全身第六大常见肿瘤,近年来线粒体DNA异常在喉、甲状腺、鼻咽、涎腺和口腔粘膜肿瘤中均有报道。对线粒体DNA异常的深入研究将为揭示肿瘤发生发展机制、寻找新的治疗手段奠定基础。
作者 许洪波 黄志刚
机构地区 首都医科大学 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科
出处 《国际耳鼻咽喉头颈外科杂志》 2006年第1期15-18,共4页 International Journal of Otolaryngology-Head and Neck Surgery
基金 北京市自然科学基金资助项目(7042011)
关键词 DNA 线粒体(DNA Mitochondrial) 突变(Mutation) 头颈部肿瘤(Head and NECK Neoplasms)
分类号 R739.91 [医药卫生—肿瘤]
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参考文献29

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共引文献10

同被引文献16

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国际耳鼻咽喉头颈外科杂志
2006年 第1期

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