摘要
【目的】探讨接受全喉切除术晚期喉癌的复发、预后情况,以及影响复发的因素。【方法】回顾性研究1992-1999年行全喉切除术的晚期喉癌111例,对其生存、复发情况及影响复发的临床病理因素进行分析。【结果】接受全喉切除术的晚期喉癌总的3、5年生存率61.3%、53.8%。总复发率35.1%(39/111),其中原发灶复发率9.0%(10/111),颈部复发率26.1%(29/111)。原发灶出现复发影响预后(P=0.0000);颈部出现复发亦影响预后(P=0.0113)。原发灶1年内复发占90%(9/10);颈部复发1年内占75.9%(22/29),2年内复发占93.1%(27/29)。全喉切除术后有无放疗(P=0.032)、切缘状态(P=0.008)影响原发灶复发;N分期(P=0.027)、病变部位(P=0.028)影响颈部复发。【结论】接受全喉切除术的晚期喉癌有较高的复发率;原发灶、颈部复发均影响预后;复发多在术后1年内;全喉切除术后有无放疗、切缘状态影响原发灶复发;N分期、病变部位影响颈部复发。
[Objective] This study was to explore the recurrence and prognosis of advanced laryngeal patients received total laryngectomy, and correlated factors of recurrence. [Methods] A total of 111 advanced laryngeal patients received total laryngectomy from 1992-1999 were retrospectively reviewed. The recurrence, prognosis, and correlated factors of recurrence were investigated. [Results] The overall 3- and 5-year survival rates of advanced laryngeal patients received total laryngectomy were 61.3% and 53.8%, respectively. The overall recurrent rate was 35.1% （39/111）, the local recurrent rate was 9.0% （10/111）, the regional recurrent rate was 26.1% （29/111）. There was statistic difference in survival between the patients with local recurrence and no local recurrence （P=0.0000）; and also between the patients with regional recurrence and no regional recurrence （P=0.0113）. Most patients developed local recurrent within 1 year 90% （9/10） and 75.9% （22/29） of regional recurrence was within 1 year and 93.1% （27/29） within 2 year. Patients who received post-operative radiation or not （P=0.032） and surgical margin （P=0.008） affected local recurrence; N stage （P=0.027） and location （P=0.028） affect regional recurrence. [Conclusion] Advanced laryngeal patients who received total laryngectomy have high recurrent rate. Local and regional recurrence affect survival. Most recurrences occur within 1 year. Post-operative radiation or not and surgical margin affect local recurrence. N stage and location affect regional recurrence.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2006年第2期232-235,共4页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广州市科技计划项目(303041080002)
关键词
喉肿瘤
全喉切除术
复发
预后
laryngeal neoplasm
prognosis
recurrence
total laryngectomy
