摘要
【目的】了解生存蛋白Survivin在T细胞非霍奇金淋巴瘤(T-NHL)中的表达,以及Survivin表达与预后的关系。【方法】用免疫组化S-P法检测83例T细胞NHL组织Survivin表达情况,分析Survivin表达与预后的关系。【结果】Survivin表达阴性10例(12%),表达阳性73例(88%),Survivin表达与病理类型、性别、年龄、B症状、结外病变数、PS、分期、LDH水平、IPI等临床特征均无相关性(P>0.05)。78例接受了化疗,大多数采用CHOP方案化疗,全组CR率45%,有效率86%,Survivin阴性者CR率60%,阳性者43%(P>0.05)。中位随访22月(1～76月),全组5年生存率31%,Survivin表达阳性的T-NHL患者5年生存率明显低于Survivin表达阴性患者(21%比70%,P<0.001)。多因素分析显示Survivin表达是T细胞NHL的独立预后指标。【结论】Survivin在T细胞NHL表达上调,Survivin阳性T-NHL患者5年生存率低于Survivin阴性者,Survivin表达可能为T细胞NHL预后的独立指标。
[Objectives ] This study was designed to evaluate the expression of survivin in T-cell non-Hodgkin＇s lymphoma （T-NHL） and the correlation of survivin expression and prognosis. [Methods] Expression of survivin in T- NHL tissues were detected by immunohistochemical staining （S-P method）. The relationship between survivin expression and prognosis were analyzed among 83 patients. [Results] Ten patients showed negative survivin expression （12%）, Seventy-three showed positive survivin expression （88%）. Survivin expression was not related to the pathological subtypes, stage, LDH, extranodal sites, B symptoms and IPI score in our study （P 〉0.05）. Most of the patients were treated by combined chemotherapy （CHOP regimen）. The overall response rate was 86% with 45% complete remission （CR） rates. The patients with positive survivin expression tend to be lower in CR rate （43% vs 60%, P 〉0.05）. The 5-year overall survival for the patients with negative survivin expression was longer than that of the patients with positive survivin expression （21% vs 70%, P〈 0.001）. The results of multivariant analysis showed survivin was an independent prognostic factor for T-NHL. [Conclusion] Up-regulation of survivin expression in T- NHL is observed in our study. The 5-year overall survival of the patients with positive survivin was shorter than that of the patients with negative survivin expression. Expression of survivin may be an independent prognostic factor for T-NHL based on our study.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2006年第2期221-224,231,共5页
Journal of Sun Yat-Sen University:Medical Sciences
