摘要
目的观察中晚期食管癌的血供特点,探讨灌注化疗对中晚期食管癌的治疗效果和并发症的防治。方法86例中晚期食管癌患者均采用Seldinger技术行相应节段的供血靶动脉选择性插管和造影,并经导管灌注化疗药物。结果本组共进行介入治疗203次,插管造影和灌注化疗成功率为100%。DSA发现肿瘤由2支或2支以上多支供血者占92.8%,单支供血者占7.2%。86例患者经介入治疗后近期临床疗效总有效率为87.8%。1、2、3年生存率分别为86.5%、39.2%和31.1%。并提示多次治疗的疗效明显优于单次治疗(χ2=7.15,P<0.01)。2年以上长期生存者,均为多次治疗。本组均未出现与造影和治疗相关的严重并发症。结论中晚期食管癌介入治疗,疗效显著、创伤小,可作为中晚期食管癌患者的首选治疗方法。
Objective To observe the blood supply of advanced esophageal carcinoma and evaluate the therapeutic effect and the prevention of complications via chemotherapy. Methods Eighty-six patients with advanced esophageal carcinoma were involved in this study. All of them were punctured via Seldinger technique and angiography, the target vessels were obtained and chemotherapy via catheter were performed. Results There were overall 203 interventional procedures were done and the success rate was 100%. Digital subtraction angiography （DSA） showed that the tumor was supplied blood by 2 or more than 2 vessels in 92.8% patients, 7.2% patients by single vessel. On short-time follow up, 87.8% patients were found responsive to the treatment. The survival rate at 1, 2, 3 year was 86.5%, 39.2%, and 31.1% respectively. The effect of more than one-time therapy was superior to patients with single treatment. The disappearance of tumor stain and tumor vessel was also markedly frequent in patients who treated several times. No complications associated with the angiography and therapy was observed. Conclusion Treating the advanced esophageal carcinoma via interventional technique is high effective with minimal injury and can be regarded as the first choice for these patients.
出处
《中国介入影像与治疗学》
CSCD
2006年第2期92-95,共4页
Chinese Journal of Interventional Imaging and Therapy
关键词
放射学
介入性
食管肿瘤
化学疗法
灌注
导管插入术
Radiology, interventional
Esophageal neoplasms
Chemotherapy
Perfusion
Catheterization
