摘要
动脉平滑肌细胞内脂过氧化物含量增加，超氧化物歧化酶活性减弱，与动脉粥样硬化的发生有着重要的关系．本实验通过对家兔主动脉平滑肌细胞进行体外培养，观察到中药疏肝活血方可以显著降低平滑肌细胞内脂过氧化物含量，明显提高超氧化物歧化酶活性。实验结果提示中药疏肝活血方可能有使动脉粥样硬化病变减轻和趋向静止的作用。
The etiology pathology etc of atherosclerosis (As) have been studied widely for many years. From the traditional medicine viewpoint,the mechanism of stasis exsisted in As. So the Chinese drug recipe of removing stagnancy of vital energy of the liver and invigorating blood circulation was subjucted in treatment of As. From the molecullar level of cytobiology, the effect of Chinese drugs on content of lipid peroxide (LPO) and activity of superoxide dismutase (SOD) were studied in vitro cultured SMC of rabbit aorta. The results showed that content of LPO in SMC were lower in Chinese drugs group than that in the control group (P<0. 01), activity of SOD in SMC were higher in Chinese drugs group than that in the control group (P< 0. 01). This Chinese drug recipe may obviously ruduce the content LPO of SMC, raise the activity of SOD, protect the normal function,metabolism and complete constitution. Thus, the Chinese drug recipe reduce the pathological changes of make it tend to motionless.
出处
《中国动脉硬化杂志》
CAS
CSCD
1996年第1期51-53,共3页
Chinese Journal of Arteriosclerosis
关键词
疏肝活血药方
平滑肌细胞
超氧化物歧化酶
Chinese drug recipe of removing stognancy of vital energy of the liver and invigoratingblood circulation
Smooth muscle cell
Content of lipid peroxide
Activity of superoxide dismutase
Atherosclerosis
