摘要
目的观察辛伐他汀对慢性充血性心力衰竭长期疗效的影响。方法119例慢性充血性心力衰竭患者,随机分成辛伐他汀组(治疗组,n=60例),常规治疗组(对照组,n=59例)。所有心力衰竭患者均给予常规治疗,治疗组加用辛伐他汀20mg,每晚1次。治疗前、治疗3、12、24个月,所有患者均查血脂、高敏C反应蛋白(hsCRP)、心率(HR)、心脏超声彩色多普勒和6min步行距离。观察所有患者的住院次数、病死率。结果辛伐他汀治疗组与对照组比较,治疗3、12、24个月后,血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、hsCRP和HR均有不同程度的降低,LVEF则有明显提高(P<0.01)。治疗组和对照组比,住院次数减少,但差异无显著性(P>0.05);6min步行距离明显增加,病死率明显降低,两组相比差异有显著性(P<0.01)。结论辛伐他汀治疗慢性充血性心力衰竭疗效明显,并且能改善患者的预后。
[Objective] To study the long-term effects of simvastatin in the patients with chronic congestive heart failure. [Methods] 119 patients with chronic congestive hea,＇t failure we,＇e divided randomly into two groups： the treatment group （n=60）, who received simvastatin 20 mg QN, and the control group （n=59）. All patients with chronie congestive heart failure were treated by conventional therapy. The total cholesterol （TC）, LDL-C, hsCRP, HR, the distance of 6 minutes＇ walk and color Doppler ultrasonography of heart were examined immediately before and 3, 12, 24 months afte the treatment. [Results] Compared with the control group, TC, LDL-C, hsCRP, HR of the patients in the treatment group we,, all degrade to different degrees and the LVEF was elevated obviously （P 〈0. 01）. The frequency of hospitalization was lower than that in the control group, but was not significantly different; the distance of 6 minutes＇ walk was increased obviously and the dead rate was significantly lower than that in the control group （P 〈0.01）. [Conclusion] The therapy of simvastatin has good effects in improving heart function and the prognosis of patients with chronic congestive heart failure.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第6期914-917,共4页
China Journal of Modern Medicine
