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充血性心衰患者血清地高辛浓度监测 被引量:1

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摘要 目的:研究地高辛血清浓度不同时对充血性心衰(CHF)的影响。方法:我院于2005年4月~同年12月采用电化学发光免疫法对54例CHF患者进行了6S次血清地高辛浓度监测,分三组:0.5~1.0ng/mL组(A组)、1.01~2.0ng/mL组(B组)和〉2.0ng/mL组(C组)。结果:A组1周内心功能显著改善率为96%。病死率为3.8%.显著好于C组(P〈0.01)。C组1周内心功能显著改善率为45.5%,且病死率36.4%,显著差于A组和B组(P〈0.01).C组病例内生肌酐清除率较A组和B组显著减退(P〈0.05)。结论:地高辛治疗充血性心衰在血药浓度0.5~1.0ng/mL时最安全、有效。病死率最低。内生肌酐清除率减退是影响血清地高辛浓度的因素之一.
出处 《实用临床医学(江西)》 CAS 2006年第3期26-27,共2页 Practical Clinical Medicine
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  • 1Saif R,Jepthap C,Yongtei W,et al.Association of serum digoxin concentration and outcomes in patients with heart failure[J].JAMA;2003,289:871-878.

同被引文献11

  • 1曲静伟,董文雅,洪中立.地高辛的血清浓度监测和剂量探讨[J].现代实用医学,2005,17(9):560-560. 被引量:5
  • 2韩鸿玲,林珊,翟德佩,邱明才.血浆内源性地高辛样因子在肾病综合征中的变化[J].天津医药,2006,34(10):686-687. 被引量:3
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