摘要
目的观察依达拉奉在神经外科常见疾病中的临床应用效果及安全性。方法选择40例神经外科常见疾病伴有神经功能缺失患者,静滴依达拉奉30mg,2次/d,共10天,治疗前后分别予以ESS评分和ADL评分。结果治疗后ESS评分为(80.2±11.4)分,较治疗前的(62.5±10.3)显著升高(P<0.01),ADL评分(78.5±18.2)较治疗前(56.4±21.2)显著升高(P<0.01),显效率70%(28/40),有效率92.5%。治疗期间未见有不良反应发生。结论依达拉奉作为新开发的一种自由基清除剂,可以安全而且有效的应用于神经外科各种合并有脑损伤的疾病中。
Objective To investigate the clinical efficacy and safety of Edaravone in some neurological disease. Methods 40 patients with neurological function scarcity in brain surgery department were given Edaravone at the dosage of 30 mg bid for 10 days, and were appraised before and after the treatment by European Stroke Scale （ESS） and Activity of Daily Living （ADL）. Rusults The ESS score increased statistically （ P 〈 0.01 ） from 62.5±10.3 （ before treatment） to 80.2±11.4, and ADL also increased statistically （ P 〈 0.01 ） from 56.4±21.2 （ before treatment） to 78.5±18.2. The statistical efficacy was 70% and total efficacy was 92.5%. No serious adverse effects were observed. Conclusions As one newly developped free radical scareger,Edaravone may be effective and safe in the treatment of patients with brain injury.
出处
《临床神经外科杂志》
CAS
2006年第1期27-28,共2页
Journal of Clinical Neurosurgery
关键词
脑损伤
依达拉奉
疗效
brain injury
edaravone
therapeutic effectiveness
