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细胞色素P450与肺癌关系的研究进展

Advances in the Research of the Correlation between CYP450 and Lung Cancer
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摘要 细胞色素P450(CYP450)属血红蛋白类酶,是微粒体混合功能氧化酶系中最重要的一族氧化酶,分布在生物体内的各种器官组织,其作用底物非常广泛,参与机体内大部分外源性、内源性致癌物质以及抗癌药物的代谢。不同的CYP450分别代谢不同的致癌物质以及抗癌药物。现已证实CYP450家族中许多酶都具有基因多态性,其多态性在人群中的分布与多种肿瘤的易感性以及抗肿瘤药物的代谢密切相关。 Cytochrome P450 （CYP450） is a kind of enzyme which belongs to hemoglobin. It is the most important oxidase of the microsomal mixed-function oxidase, and is distributed in a variety of tissues of organisms. Its substrate is extensively found, so it is involved in a good many metabolic events of the exogenous and endogenous carcinogens and anticancer drugs. Different CYP450 can metabolize different carcinogens and anticancer drugs. It has now been confirmed that there are many genetic polymorphisms in the CYP450 Family, and the distribution of the polymorphism is correlated to the susceptibility to lung cancer and the metabolism of the anti-tumor drugs.
作者 于庆忠 韩金祥 高雪芹 潘继红
机构地区 山东省医药生物技术研究中心国家卫生部生物技术药物重点实验室
出处 《医学分子生物学杂志》 CAS CSCD 2006年第2期153-155,共3页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.30471979)~~
关键词 细胞色素P450 肺癌 相关性 cytochromeP450 lung cancer correlation
分类号 R394.3 [医药卫生—医学遗传学] R734.2 [医药卫生—肿瘤]
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参考文献18

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医学分子生物学杂志
2006年 第2期

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