摘要
目的探讨白细胞介素-8(IL-8)与慢性阻塞性肺疾病(COPD)的关系及其作为判断预后的作用。方法采用放射免疫分析法,对45例COPD急性发作期患者治疗前及10～14d病情缓解后分别测定外周血清的IL-8水平,并与10例正常对照者相比较。结果COPD急性发作时外周血清IL-8明显高于缓解后水平(P<0.01),且非存活组患者外周血IL-8水平显著高于存活组(P<0.01)。结论IL-8参与COPD的气道炎症反应。高水平的血清IL-8提示预后不良。
Objective To study whether Interleukin -8 was involved in chronic obstructive pulmonary disease（COPD）. Methods Serum IL -8 levels of 45 cases of acute exacerbations and in the stable period with treatment for 10 - 14 days were assaied by RIA, and compared with 10 normal controls. Results The levels of IL -8 in cases during exacerbation were significantly higher than those in stable period （ P 〈 0.01 ） ,and the level of serum IL -8 was significantly higher in the non - survivors than in the survivors among these cases （ P 〈 0.01 ）. Conclusion These findings indicated that IL- 8 was involved in the airway inflammatory reaction of chronic obstructive pulmonary diseases. High levels of serum IL -8 could predict a poor prognosis for them.
出处
《中原医刊》
2006年第6期13-14,共2页
Central Plains Medical Journal
关键词
慢性阻塞性肺疾病
气道炎症
细胞因子
IL-8
Chronic obstructive pulmonary diseases
Airway inflammation
Cytokine
IL - 8
