摘要
部分精神分裂症患者有脑萎缩改变，但这些病人长期服用氯丙嗪等神经阻滞剂。脑萎缩究竟因精神分裂症自然病程的演变所致，还是抗精神病药所致，值得研究。我们以白鼠作实验研究，每组１０只，共３组，分别注射氯丙嗪、灌入左旋多巴和不使用药物作为对照。结果发现，左旋多巴灌入组的大脑皮层及间脑有广泛的胶质细胞增生，形成胶体结节，神经元有空泡样变性和神经细胞缠结；而氯丙嗪组与对照组无显著变化。以精神分裂症患者多巴胺活动亢进学说来看，可能表示精神分裂症患者的脑萎缩并非氯丙嗪所致。
bjective:To assess the effects of levodopa (dopamine agonist) and chlorpromazine (dopamine antagonist) on the brain morphology of rats,and to speculate on the nature of brain atrophy in schizophrenic patients.Method:20 rats which were given intravenous chlorpromazine (10) or levodopa (10) were compared with a control group of 10 rats without drug treatment.Results:There was no morphological change in the brains of rats which were given chlorpromazine,and of rats in the control group.By contrast,rats which received levodopa manifested marked changes in brain morphology,including proliferation of neuroglia cells and formation of neuroglia node,especially in the mesencephalon.Discussion:These findings in rats suggested that brain atrophy in schizophrenic patients may be due to hyperfunction of dopamine rather than neuroleptic treatment.Similarly,longterm neuroleptic treatment may slow atrophic brain changes.Further studies are recommended.
出处
《临床精神医学杂志》
1996年第3期131-132,共2页
Journal of Clinical Psychiatry
