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S期激酶相关蛋白2与恶性血液病

S-phase kinase associated protein2and hematologic malignancies
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作者 韩利杰
机构地区 郑州大学第一附属医院血液内科
出处 《河南医学研究》 CAS 2006年第1期89-91,94,共4页 Henan Medical Research
关键词 恶性血液病 S期激酶相关蛋白2 细胞周期调控机制 F-BOX蛋白 Skp2 肿瘤恶性程度 肿瘤发生 生物学特性 家族成员 多种肿瘤
分类号 R733 [医药卫生—肿瘤] R733.72 [医药卫生—肿瘤]
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参考文献27

  • 1Schulman BA,Carrano AC,Jeffrey PD,et al.Insights into SCF ubiquitin ligases from the structure of the skp1-skp2 complex [ J ].Nature,2000,408(6810):381-386.
  • 2Pagano M.Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2axis[J].Mol Cell,2004,14(4):414-416.
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  • 4Ungermannova D,Gao Y,Liu X.Ubiquitination of p27 Kip1 requires physical interaction with cyclinE and probable phosphate recognition by SKP2[J].J Biol Chem,2005,280 (34):30301-30309.
  • 5Hao B,Zheng N,Schulman BA,et al.Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase[J].Mol Cell,2005,20(1):9-19.
  • 6Harper JW.Protein destruction:Adapting roles for Cks proteins[ J].Curr Biol,2001,11 (11):431-435.
  • 7Sitry D,Seeliger MA,Ko TK,et al.Three different binding sites of Cks1are required for p27-ubiquitin ligation [ J ].J Biol Chem,2002,277 (44):42233-42240.
  • 8Kitajima S,Kudo Y,Ogawa I,et al.Role of Cks1 overexpression in oral squamous cell carcinomas:cooperation with Skp2 in promoting p27 degradation[J].Am J Pathol,2004,165(6):2147-2155.
  • 9Ji P,Zhu L.Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression [ J ].Cell Cycle,2005,4 (3):373-375.
  • 10Ji P,Jiang H,Rekhtman K,et al.An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant[J].Mol Ce11,2004,16(1):47-58.

二级参考文献12

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  • 3Pagano M, Tam SW, Theodoras AM, et al. Role of the ubiquitin-proteosome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 [J]. Science, 1995, 269:682 - 685.
  • 4Carrana AC, Eytan E, Hershko A, et al. Skp2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 [J]. Nat Cell Biol, 1999, 1:193 - 199.
  • 5Skorski T, Szczylik C, Malaguamera L, et al. Gene-targeted specific inhibition of chronic myeloid leukemla cell growth by BCR-ABL antisense oligodeoxynucleotides[J]. Folia Histochem Cytobiol, 1991, 29:85 - 89.
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  • 8Few ML, Randel E, Gurley KE, et al. The murine genep 27Kip1 is haplo-insufficient for tumour suppression[J]. Nature,1998, 396:177 - 180.
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河南医学研究
2006年 第1期

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