摘要
目的探讨水杨酸钠腹腔注射对小鼠畸变产物耳声发射(distortion product otoacoustic emission,DPOAE)的影响及其特征。方法测试小鼠用药前畸变产物耳声发射的基线水平;随后按400 mg/kg 腹腔注射水杨酸钠;分别在腹腔注射后3 h 和3 d 再次检测小鼠畸变产物耳声发射。结果用药后3 h,小鼠 f_2为5、6、7和8k Hz 的2 f1-f_2DPOAE 阈值上升了12～15 dB SPL,而 DPOAE 的幅值则下降了3～9 dB SPL;在用药后3 d,小鼠 DPOAE 的阈值和幅值均恢复到用药前基线水平。用药后,原始音为60 dB SPL 时所诱发的各频率 DPOAE 检出率明显低于原始音为70 dB SPL 的检出率,且检测频率越低检出率越低。用药前后小鼠 DPOAE 的潜伏期无显著变化。结论水杨酸钠可逆性地引起小鼠 DPOAE 阈值升高和幅值降低,这种变化在低强度原始音诱发的DPOAE 较明显,而对潜伏期无明显影响。
Purpose To study the effects of sodium salicylate, injected intraperitoneally at dosage of 400 mg/kg, on distortion product otoacoustic emission （DPOAE） in mice.Methods DPOAEs were measured as baseline before administration. Then DPOAEs were measured again after 3 hours and 3 days of drug administration. Results After 3 hours of drug administration, the thresholds and magnitudes of DPOAE at the 2 fl- f2 frequency increased 12～ 15 dB SPL and decreased 3 ～ 9 dB SPL, respectively. After 3 days of drug administration, the thresholds and magnitudes returned to the baseline level. On the contrary ,the latencies of DPOAE were not affected by sodium salicylate statistically. After 3 hours of drug administration,the incidence rates of DPOAE induced by the primaries at 60 dB SPL over 5,6,7,8 kHz frequencies were much lower than the incidence rates induced by the primaries at 70 dB SPL. And the incidence rates of the lower frequencies lower than the higher frequencies. Conclusion Sodium salicylate can increase the thresholds and reduce magnitude of DPOAE in mice reversibly and the change were significant induced by lower-level primaries. Sodium salicylate had no effects on the latencies of DPOAE in mice. （Chin J Ophthalmol and Otorhinolaryngology,2006,6：86 - 88）
出处
《中国眼耳鼻喉科杂志》
2006年第2期86-88,共3页
Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词
水杨酸钠
畸变产物耳声发射
小鼠
sodium salicylate
distortion product otoacoustic emission
mouse
