摘要
目的研究慢性肝炎（ＣＨ）及肝硬变（ＬＣ）患者强力宁对腺苷脱氨酶（ＡＤＡ）的影响。方法用Ｇｉｕｓｔｉ比色法检测ＣＨ２６例，ＬＣ２０例患者血浆及外周血单个核细胞（ＰＢＭＣ）的ＡＤＡ活力。结果ＣＨ及ＬＣ患者血浆ＡＤＡ活力（４７．５±１５．９及３９．２±１０．３ｍｍｏｌＮＨ／Ｌ）明显高于正常人（２７±６．７ｍｍｏｌＮＨ３／Ｌ，Ｐ＜０．０１）；ＰＢＭＣＡＤＡ活力（２１．７±７．６及１８．４±７．５ｍｍｏｌＮＨ３／１０７ｃｅｌｓ）较正常人（２９±５．７ｍｍｏｌＮＨ３／１０７ｃｅｌｓ，Ｐ＜０．０１）为低。ＰＢＭＣＡＤＡ活力与血浆ＡＤＡ活力不相关。强力宁治疗８周后，ＰＢＭＣＡＤＡ活力明显升高（Ｐ＜０．０１，与正常人接近。
AIMS To study the effect of potenlin (main component is glycyrrhize) of adenosine deaminase(ADA) activities in patients with chronic hepatitis(CH) and liver cirrhosis(LC). METHODS ADA activities in plasma and peripherial blood mononuclear cells(PBMC) were determined with Guisti′s colorimetry. RESULTS Plasma ADA activty in 26 patients with CH and 20 with LC(47.5±15.9 and 39.2±10.3mmol NH 3/L) was significantly higher than that of normal control(27±6.7mmol NH 3/L, P<0.01); whereas PBMC ADA activity in both groups(21.7±7.6 and 18.4±7.5mmol NH 3/10 7 cells) was lower than normal control (29±5.7mmol NH 3/10 7 cells, P<0.01). After 8 weeks of potenlin therapy in 14 patients with CH, PBMC ADA activity increased significantly and almost reached normal level. CONCLUSIONS In patients with CH and LC, potenlin results in immunological regulation by the recovery of PBMC ADA activity.
关键词
腺苷脱氨酸
肝疾病
强力宁
药理学
hepatitis B/enzymology adenosine deaminase/blood liver cirrhosis/enzymology glycyrrchizin/therapentic use drug combinations
