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X连锁非特异性精神发育迟滞相关基因功能研究进展 被引量：5

Progress of Functional Study on MRX Related Genes
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摘要 X连锁非特异性精神发育迟滞相关基因是一类目前研究较多的基因,其突变或缺失患者仅具有一般或特殊认知功能障碍的单纯表现型。从生物学功能和认知功能两方面研究X连锁非特异性精神发育迟滞相关基因,不仅对弄清非特异性精神发育迟滞的遗传基础有重要意义,而且还能开拓出研究人类认知功能的分子遗传机理的新领域。文章就目前对X连锁非特异性精神发育迟滞相关基因的生物学功能和认知功能的研究现状,及该研究方向的发展前景进行了综述。 X-linked nonspecific mental retardation （MRX） related genes are a group of extensively studied genes whose mutation or deletion results in simple phenotypes of generalized or specific cognitive impairment in patients, such as, low intelligence and poor social adaptability. Studying the biological and cognitive functions of MRX related genes means much not only to the discovery of the genetic basis for non-specific MR, but also to the exploration into a new field of research about the molecular basis of human cognitive function. This paper summarizes recent progress on MRX studies, the current status and the prospect of this field.
作者 张科进 张富昌 高晓彩
机构地区 西北大学生命科学学院人口与健康研究所
出处 《遗传》 CAS CSCD 北大核心 2006年第4期501-506,共6页 Hereditas（Beijing)
基金 国家自然科学基金项目(编号:30470577) 国家十五科技攻关计划项目(编号:2001BA901A49)资助~~
关键词 非特异性精神发育迟滞 基因 认知功能 nonspecific mental retardation gene cognitive function
分类号 Q343 [生物学—遗传学]
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参考文献30

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