摘要
以左旋氧氟沙星(LVFX)为模板,以α-甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,采用热聚合方式,通过条件优化获得了对左氧氟沙星有特异选择性吸附的分子印迹聚合物(M IPs)。最优化条件为n(LVFX)∶n(MAA)∶n(EDMA)=1∶4∶15,聚合温度60℃,聚合时间48 h,溶剂氯仿,用量10 mL。通过结合实验分析,在最优化条件下制得的M IPs对左氧氟沙星具有很好选择性和吸附能力,分离因子α(LVFX/OLFX)为1.56。
Molecularly imprinted polymers （MIPs） of levofloxacin （LVFX） with recognition properties by thermalpolymerization method were prepared using levofloxacin as templates, methyacrylic acid as functional monomers andethylene dimethacrylate as crosslinker under the optimized conditions. The binding experiments of MIPs to LVFXwere used to evaluate the influences of various factors on LVFX binding. The optimizing conditions were thatn（LVFX） ： n（MAA） ： n （EDMA） = 1 ： 4： 15, polymerization temperature was 60℃, polymerization time was 48hours and solvent was chloroform, the volume of chloroform was 10 mL. The experimental results indicated that theMIPs had higher LVFX binding capacity than OFLXs and also higher than corresponding non-imprinted polymers, itwas found that the highest separation factor （α） of the MIPs to LVFX/OFLX could reach to be 1.56.
出处
《南京工业大学学报（自然科学版）》
CAS
2006年第1期41-45,共5页
Journal of Nanjing Tech University(Natural Science Edition)
基金
上海市重点学科科研基金资助
关键词
左旋氧氟沙星
分子印迹聚合物
热聚合
手性识别
levofloxacin （LVFX）
molecularly imprinted polymer
thermal polymerization
chiral recognition
