摘要
目的探讨父母亚甲基四氢叶酸还原酶(MTHFR)基因C677T、胱硫醚β-合酶(CBS)基因T833C、环境因素与子代先天性心脏病(CHD)发生之间的关联。方法采用1∶1配对病例对照研究方法,分析115对CHD患儿与对照儿父母的环境暴露因素,并检测其MTHFR与CBS基因型,对CHD可能的危险因素进行单因素及多因素条件logistic回归分析。结果母亲怀孕早期接触农药(OR=8.62)、妊娠合并症(OR=2.069)、孕早期感冒(OR=4.125)、孕期情绪状况(OR=4.653)、母亲MTHFR基因677TT型(OR=3.872)共5个因素为子代发生CHD的危险因素。结论母亲MTHFR基因677TT型与子代CHD发生有关,未发现父母CBS基因T833C与子代CHD存在关联,母亲怀孕早期接触农药、妊娠合并症、孕早期感冒、孕期情绪紧张或忧郁可能增加子代发生CHD的危险。
Objective To explore congenital heart diseases（CHD） in their offsprings in association with parental methylenetetrahydrofolate reductase（MTHFR） gene C677T, cystathionine β- synthase（CBS） gene T833C,and environmental factors. Methods A 1 ： 1 case-control study was carried out to investigate llSpairs of case and controled children and their parents, and the parents＇ MTHFR gene 677 C→T mutation and CBS gene 833 T→C mutation were also identified. The possible risk factors were analysed by simple and multiple factors logistic regression methods. Results Results revealed that 5 factors were related to the occurrence of CHD in the offsprings： maternal exposures to pesticides in the early stage of pregnancy （OR = 8.62）, suffering from diseases during pregnancy（ OR -2. 069）, catching cold in the early stage of pregnancy（ OR = 4. 125 ）, under depressed or nervous condition during pregnancy（ OR = 4. 653 ）, maternal MTHFR 677TT genotype（ OR = 3.872）. Conclusion These results suggested that maternal MTHFR 677TT genotype was one of the risks to the occurrence of CHD in offspring but parents＇ CBS gene 833 T→C mutation did not get involved in CHD. In addition,the occurrence of CHD was related to maternal exposures to pesticides,catching a cold, suffering from dlseases,depressed or under nervous condition in the early stage of pregnancy or during pregnancy.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2006年第3期260-263,共4页
Chinese Journal of Epidemiology
基金
广西壮族自治区自然科学基金资助项目(0448049)
关键词
先天性心脏病
亚甲基四氢叶酸还原酶
胱硫醚Β-合酶
基因
环境因素
Congenital heart disease
Methylenetetrahydrofolate reductase
Cystathionine β- synthase
Gene
Environmental factors
